The Endocannabinoid System:

Tetrahydrocannabinol (T.H.C) And Cannabidiol (C.B.D)


Hemp and marijuana are both types of the cannabis Sativa plant, but they’re bred differently and have different biological attributes. Most importantly, hemp does not have psychoactive properties, because it has far lower levels of tetrahydrocannabinol (THC) than marijuana. The two plants look different, hemp stalks are long, thin, and fibrous, while marijuana grows closer to the ground and are shorter. These two plants differ in their cannabinoid ratios but come from the same plant species Cannabis Sativa L.

Cannabis contains numerous molecules, including more than 75 chemical compounds classified as cannabinoids, and the different Cannabis chemotypes vary in their cannabinoid composition. The two most extensively studied phytocannabinoids (natural plant cannabinoids) are D9 tetrahydrocannabinol (THC) and cannabidiol (CBD). Other active phytochemicals include Terpenes and Phenolic Compounds such as flavonoids.


Given this history, the broad reach of cannabis medicine should not be a surprise. The endocannabinoid system has been involved in cell protection for 600 to 800 million years. Everything about you that is different from a sponge evolved with endocannabinoids doing inflammation and oxidation control.


The Endocannabinoids are the molecules that act as chemical messengers that bind to cannabinoid cell receptors and tell the body to do certain things. The human body naturally produces endocannabinoids with the help of consuming foods like fatty acids found in nuts and fish. The 60 cannabinoid molecules found in the cannabis plant also can bind to cannabinoid receptors. Although different cannabinoids (like CBD and THC) cause different effects, it is all through the same system that similar molecular messages are sent throughout the body. Get more information about kostenlos spielen book of ra deluxe ohne anmeldung. Put more simply, the molecules found in cannabis plants aid in the human body’s endocannabinoid system, which is responsible for many vital functions.

With CB1 and CB2 receptors in our body system, the endocannabinoids became a channel for communication between cells. This system has developed so that it manages communication between brain regions, tissues, and whole organs.

This endocannabinoid system acts as the trigger boss of the body as opposed to the brain. According to Dr. Rachel Knox, The endocannabinoid system resides in all animals except the insect, and it is a 600 million neuro-messenger and receptor system controlling the hemostasis (management of balance) within the body. It is like a switchboard functioning across all physiological processes and organs acting and reacting to external stimuli to direct, correct, and manage our overall health.


Endocannabinoids are produced in response to both inflammation and oxidative stress. The chemical reaction that creates them is triggered when calcium levels rise, and both inflammation and oxidative stress cause calcium to rise. If calcium gets too high, mitochondria will kill the cell. Endocannabinoids have direct chemical effects and they act as a broadcast signal that says “if calcium doesn’t come down, we’re all dead”.

The system was found to be directly involved in the processes that keep our bodies balanced day to day, including appetite, pain-sensation, mood, memory, immune system functions, and inflammation control. Essentially, the system helps to manage homeostasis, balancing our body’s natural conditions. This system is made up of receptors that are located in the brain and nervous systems throughout the body

The endocannabinoid system can be broken down into four core component:

The Body receptors which are CB 1 and CB 2, bind the ligands and initiate an action called endocannabinoid or body made cannabinoids like Anandamide and 2AG. As well as the synthesizing enzymes that make this endocannabinoid available on demand when they are needed and the degrading enzymes that break them down when they are used.

At human conception, when the sperm meets the egg, the new cell immediately releases cannabinoids, deactivating other sperm and helping prevent multiple fertilization. Additional cannabinoid signaling negotiates the gamete’s journey to the uterus and implantation on the uterine wall. When you were a single cell, you relied on cannabinoid signaling to navigate your world.


In 1940, American organic chemist, Roger Adams, was the first person to isolate the CBD compound. Twenty-four years later, Raphael Mechoulam, known as the “father of cannabis” was credited with the isolation of THC as well as elucidating the entire cannabidiol structure. Then, in the 1980s, President Ronald Reagan poured tens of millions of dollars into a study to prove that marijuana damages the human brain. But, rather than showing how marijuana harms the brain, the Reagan administration ended up subsidizing a series of studies that culminated in the discovery of the endocannabinoid system, expanding our understanding of how cannabinoids interact with the human body.

CBD can be extracted from marijuana or industrial hemp plants. For legality purposes, many CBD products are extracted from the stalks and stems of industrial hemp plants which are cannabis plants with .3% THC or less so they qualify as Industrial Hemp. . Ethanol and C02 extraction are two commonly used methods for extracting CBD and are two of the cleanest ways to extract CBD for human consumption.

The levels of THC in cannabis are what legally distinguish which plants are considered industrial hemp and which are considered marijuana. High levels of THC (3 -15%), the cannabinoid commonly associated with the plant’s psychoactive properties, is found in higher concentrations in marijuana plants, whereas industrial hemp status is given to cannabis plants with THC levels less than .3%. Cannabinoid ratios differ from each cannabis strain.


The CBD molecule when isolated is the same whether it was derived from marijuana or hemp. Thus, the argument of the CBD molecule being different in marijuana and hemp is a common misconception. Franjo Grotenhermen of the International Association of Cannabinoid Medicines famously declared, “CBD is CBD. The human body does not care where the molecule comes from.” To better understand this, think of drinking water from the faucet of your sink or a filtered water bottle. Although the purity of the water might be different, the H2O molecule is consistent. Similar to the above analogy, what is arguably relevant in the debate between hemp or marijuana extracts should be the purity and safety of the cannabidiol someone is consuming, regardless of the plant, it is derived from.

In 2006 a group of scientists hypothesized that there are cannabinoid receptors in human salivary glands. Their hypothesis was correct, which is most likely the reason that one of the previously discovered side effects of CBD is what’s commonly known as cotton-mouth. When CBD interacts with the endocannabinoid system, it inhibits the secretion of saliva, thus leaving some users with a dry sensation in their mouth. However, The Department of Health and Human Services states, ‘no signs of toxicity or serious side effects have been observed following chronic administration of cannabidiol to healthy volunteers, even in large acute doses of 700 mg/day.


While there are over 100 different cannabinoids that can occur in cannabis, the two most well-known and studied compounds in the cannabis plant happen to also be the two that occur in the largest volume: delta-9 tetrahydrocannabinol, commonly referred to as THC, and cannabidiol, known as CBD. Like all other cannabinoids, these two must be heated to convert the cannabinoid acid to the active cannabinoid. This process is called decarboxylation.

THC, tetrahydrocannabinol is the primary psychoactive component of cannabis which gives the effect of what recreational users call the “high.” CBD is considered to be non-psychoactive and when used in conjunction with THC helps dampen the psychoactivity and other side effects some people consider undesirable. Both cannabinoids have an impressive list of ways they support the human body.

THC is a strong anti-inflammatory and pain killer and has been shown to reduce the amyloid plaques in the brain that cause Alzheimer’s. 

In pre-clinical trials, THC has been proven to reduce levels of vascular endothelial growth factor (VEGF) in glioma (brain cancer) cells. This is important because a reduction in VEGF means that brain cancer tumors are unable to grow the new blood vessels they need to sustain themselves, grow, and spread. This discovery offers great promise for the treatment of brain cancer.

THC is also a bronchodilator, anti-spasmodic, muscle relaxant, a powerful neuroprotectant, and antioxidant. It has 20 times the anti-inflammatory power of aspirin and twice that of hydrocortisone.



In conclusion, using what we call the “Entourage” which is cannabis products that include a regulated amount of THC and CBD is a recommended method of using cannabis. An expert or Doctor in a state where it is legal should be sorted out before us.


Disclaimer: Information Purpose Only.






Dr. Rachel M Knox @Tedx Talk On The ECS